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Rett syndrome (RTT) is a rare neuro-developmental disorder (incidence: approximately one out of 10,000 female births) that reached worldwide prominence in the early 1980s. Owing to its predominance in females, Rett syndrome is regarded as a genetic disorder. Over the past 25 years, understanding of the clinical features and natural history of this unique neuro-developmental disorder has evolved dramatically. Significant advances have emerged in recent years regarding our understanding of the clinical features, molecular genetics
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