On May 15, the U.S. Food and Drug Administration approved Adakveo (crizanlizumab-tmca), a treatment to reduce the frequency of vaso-occlusive crisis – a common and painful complication of sickle cell disease that occurs when blood circulation is obstructed by sickled red blood cells – for patients age 16 years and older.
|Unmet Medical Need Parameters||Current Unmet Medical Need in vaso-occlusive crisis in sickle cell disease||Unmet Medical Need after Adakveo (crizanlizumab-tmca)|
|Low to moderate unmet medical need||Low to moderate unmet medical need|
|Disease Severity||Vaso-occlusive crisis and chronic pain are associated with considerable economic loss and disability||Vaso-occlusive crisis and chronic pain are associated with considerable economic loss and disability|
|Treatment Adequacy||Current treatment (Endari) affects episodes frequency||New treatment also affects episodes frequency|
|Concerns of Payers & Providers||• Median number of sickle cell crises|
• Median number of hospitalizations for sickle cell pain
• Median cumulative days in hospital
• Median time (days) to first sickle cell crisis
• Patients with occurrences of acute chest syndrome
|• Annual rate of VOC (vaso-occlusive crises)
• Annual rate of days hospitalized
|Net Unmet Medical Need Score||2.46/5||2.34/5|
Adakveo has disease modifying effect, affects disease severity and provides symptomatic relief as well as addresses patients, payers and providers concerns.
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We help researchers in unmet medical need analysis of diseases which helps them in disease prioritization for any new drug/device/target/MOA development. We do unmet medical need analysis of any disease based on various parameters which is not limited to treatment adequacy, patient perspective, payer & providers perspective.